Time-based conditions for synchronized procurement in Douki Seisan

This paper introduces the synchronous manufacturing philosophy (douki seisan) devised by Nissan, and relates it to “Just in Sequence”, a common technique in current automotive industry. Literature is full of case studies, and the advantages and drawbacks of JIS have been reported. However, no attempt to model the necessary relations to make this system work has been found. In this paper, the necessary conditions concerning the lead times and cycle times of the different activities are deduced, and even the moment when they should take place. They allow us to define a strongly synchronous system. For practitioners, each condition shows opportunities for process improvement. For researchers, lack of compliance with such conditions, gives rise to maximum satisfiability problems.Postprint (published version

Productivity improvement, considering legal conditions and Just In Time principles in the mixed-model Sequencing problem

A new mathematical model to solve the Mixed-Model Sequencing Problem with Work overload minimization is formulated. The model incorporates productive, social and legal aspects in order to move the theory problem closer to the actual industrial environments. Specifically, there are considered the variation of work pace of workers throughout the workday to increase the completed work; the conditions of occupancy level of workers imposed by the collective agreements; and the idea of keeping constant the production mix through the sequence leading both to a balance between the required workloads at stations and regular consumption of components. Indeed, by means of a case study linked to Nissan, a gain of over 98% is achieved in terms of regular cumulative production and required work, while performing the 100% of required work and following legal restrictions of operators’ saturation.Postprint (published version

Simple heuristics for the assembly line worker assignment and balancing problem

We propose simple heuristics for the assembly line worker assignment and balancing problem. This problem typically occurs in assembly lines in sheltered work centers for the disabled. Different from the classical simple assembly line balancing problem, the task execution times vary according to the assigned worker. We develop a constructive heuristic framework based on task and worker priority rules defining the order in which the tasks and workers should be assigned to the workstations. We present a number of such rules and compare their performance across three possible uses: as a stand-alone method, as an initial solution generator for meta-heuristics, and as a decoder for a hybrid genetic algorithm. Our results show that the heuristics are fast, they obtain good results as a stand-alone method and are efficient when used as a initial solution generator or as a solution decoder within more elaborate approaches.Comment: 18 pages, 1 figur

Condensation of a tetrahedra rigid-body libration mode in HoBaCo4O7 : the origin of phase transition at 355 K

Rietveld profiles, Moessbauer spectra and x-ray absorption fine structure (XAFS) were analyzed through the structural phase transition at Ts = 355 K in HoBaCo4O7. Excess of the oxygen content over O7 was avoided via annealing the samples in argon flow at 600 degree C. Space groups (S.G.) Pbn21c and P63mc were used to refine the structure parameters in the low- and high-temperature phases, respectively. Additionally, the Cmc21 symmetry was considered as a concurrent model of structure of the low-temperature phase. In the high-temperature phase, severe anisotropy of thermal motion of the major part of the oxygen atoms was observed. This anisotropic motion turns to be quenched as the sample is cooled below Ts. The variation of quadrupole splitting near Ts is not similar to a steplike anomaly frequently seen at the charge-ordering transition. We observe instead a dip-like anomaly of the average quadrupole splitting near Ts. Narrow distribution of the electric field gradient (EFG) over different cobalt sites is observed and explained on the basis of point-charge model. XAFS spectra show no evidence of significant difference between YBaCo4O7 (T > Ts) and HoBaCo4O7 (T < Ts). The origin of the transition at Ts is ascribed to the condensation of the libration phonon mode associated with the rigid-body rotational movements of the starlike tetrahedral units, the building blocks of kagome network. It is shown that the condensation of the libration mode is not compatible with translation symmetry for the hexagonal S.G., but compatible for the orthorhombic S.G. The orthorhombic lattice parameters and EFG components (Vxx, Vyy, Vzz) vary smoothly with temperature at approaching Ts and closely follow each other.Comment: 13 figure

A Mixed-Integer Linear Programming Model for Transportation Planning in the Full Truck Load Strategy to Supply Products with Unbalanced Demand in the Just in Time Context: A Case Study

[EN] Growing awareness in cutting transport costs and minimizing the environmental impact means that companies are increasingly interested in using the full truck load strategy in their supply tasks. This strategy consists of filling trucks completely with one product type or a mixture of products from the same supplier. This paper aims to propose a mixed-integer linear programming model and procedure to fill trucks which considers limitations of stocks, stock levels and unbalanced demand and minimization of the total number of trucks used in the full truck load strategy. The results obtained from a case study are presented and are exported in a conventional spreadsheet available for a company in the automotive industry.Maheut ., JP.; García Sabater, JP. (2013). A Mixed-Integer Linear Programming Model for Transportation Planning in the Full Truck Load Strategy to Supply Products with Unbalanced Demand in the Just in Time Context: A Case Study. IFIP Advances in Information and Communication Technology. 397:576-583. doi:10.1007/978-3-642-40361-3_73S576583397Bitran, G.R., Haas, E.A., Hax, A.C.: Hierarchical production planning: a single stage system. Operations Research 29, 717–743 (1981)Sun, H., Ding, F.Y.: Extended data envelopment models and a practical tool to analyse product complexity related to product variety for an automobile assembly plant. International Journal of Logistics Systems and Management 6, 99–112 (2010)Boysen, N., Fliedner, M.: Cross dock scheduling: Classification, literature review and research agenda. Omega 38, 413–422 (2010)Garcia-Sabater, J.P., Maheut, J., Garcia-Sabater, J.J.: A two-stage sequential planning scheme for integrated operations planning and scheduling system using MILP: the case of an engine assembler. Flexible Services and Manufacturing Journal 24, 171–209 (2012)Ben-Khedher, N., Yano, C.A.: The Multi-Item Replenishment Problem with Transportation and Container Effects. Transportation Science 28, 37–54 (1994)Cousins, P.D.: Supply base rationalisation: myth or reality? European Journal of Purchasing Supply Management 5, 143–155 (1999)Kiesmüller, G.P.: A multi-item periodic replenishment policy with full truckloads. International Journal of Production Economics 118, 275–281 (2009)Goetschalckx, M.: Transportation Systems Supply Chain Engineering, vol. 161, pp. 127–154. Springer, US (2011)Liu, R., Jiang, Z., Fung, R.Y.K., Chen, F., Liu, X.: Two-phase heuristic algorithms for full truckloads multi-depot capacitated vehicle routing problem in carrier collaboration. Computers Operations Research 37, 950–959 (2010)Arunapuram, S., Mathur, K., Solow, D.: Vehicle Routing and Scheduling with Full Truckloads. Transportation Science 37, 170–182 (2003

Global and regional effects of land-use change on climate in 21st century simulations with interactive carbon cycle

Biogeophysical (BGP) and biogeochemical (BGC) effects of land-use and land cover change (LULCC) are separated at the global and regional scales in new interactive CO2 simulations for the 21st century. Results from four earth system models (ESMs) are analyzed for the future RCP8.5 scenario from simulations with and without land-use and land cover change (LULCC), contributing to the Land-Use and Climate, IDentification of robust impacts (LUCID) project. Over the period 2006–2100, LULCC causes the atmospheric CO2 concentration to increase by 12, 22, and 66 ppm in CanESM2, MIROC-ESM, and MPI-ESM-LR, respectively. Statistically significant changes in global near-surface temperature are found in three models with a BGC-induced global mean annual warming between 0.07 and 0.23 K. BGP-induced responses are simulated by three models in areas of intense LULCC of varying sign and magnitude (between −0.47 and 0.10 K). Modifications of the land carbon pool by LULCC are disentangled in accordance with processes that can lead to increases and decreases in this carbon pool. Global land carbon losses due to LULCC are simulated by all models: 218, 57, 35 and 34 Gt C by MPI-ESM-LR, MIROC-ESM, IPSL-CM5A-LR and CanESM2, respectively. On the contrary, the CO2-fertilization effect caused by elevated atmospheric CO2 concentrations due to LULCC leads to a land carbon gain of 39 Gt C in MPI-ESM-LR and is almost negligible in the other models. A substantial part of the spread in models' responses to LULCC is attributed to the differences in implementation of LULCC (e.g., whether pastures or crops are simulated explicitly) and the simulation of specific processes. Simple idealized experiments with clear protocols for implementing LULCC in ESMs are needed to increase the understanding of model responses and the statistical significance of results, especially when analyzing the regional-scale impacts of LULCC

Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate

Endogenous creatinine clearance (Ccr) is widely accepted as an estimate of glomerular filtration rate (GFR), the best overall biomarker of kidney function. However, current common methods of measuring creatinine are not sensitive enough for mouse plasma. Accordingly, we here report a new method of measuring creatinine by liquid chromatography tandem mass spectrometry (LC-MS/MS) using deuterated [2H3]-creatinine as an internal standard. The assay requires 10 microl or less of plasma or urine, and is eight times more sensitive than high-performance liquid chromatography. The reproducibility of the assay of replicates is approximately +/-10%. The plasma creatinine levels of wild type male C57BL/6J mice obtained by LC-MS/MS are 0.076+/-0.002 mg/dl (n=65). To estimate daily urinary creatinine excretion for calculating Ccr, we collected urine from mice housed in metabolic cages, and combined this with washes from the cage internal surfaces. Creatinine in the wash varies from 4 to 67% of the total daily urinary creatinine excretion (typically approximately 400 microg/day). Ccr obtained by LC-MS/MS was 329+/-17 microl/min, which is indistinguishable from GFR measured by using fluorescein isothiocyanate-inulin. The LC-MS/MS method is sensitive, specific, simple, fast, and inexpensive; it is suitable for estimating GFR in conscious mice or other small animals. As it allows repeated measurements in the same animals, it facilitates detection of subtle differences or changes in renal function

Ordering a sparse graph to minimize the sum of right ends of edges

Motivated by a warehouse logistics problem we study mappings of the vertices of a graph onto prescribed points on the real line that minimize the sum (or equivalently, the average) of the coordinates of the right ends of all edges. We focus on graphs whose edge numbers do not exceed the vertex numbers too much, that is, graphs with few cycles. Intuitively, dense subgraphs should be placed early in the ordering, in order to finish many edges soon. However, our main “calculation trick” is to compare the objective function with the case when (almost) every vertex is the right end of exactly one edge. The deviations from this case are described by “charges” that can form “dipoles”. This reformulation enables us to derive polynomial algorithms and NP-completeness results for relevant special cases, and FPT results

Effects of the COVID-19 pandemic on medical students: a multicenter quantitative study

© 2021, The Author(s). Background: The COVID-19 pandemic disrupted the United States (US) medical education system with the necessary, yet unprecedented Association of American Medical Colleges (AAMC) national recommendation to pause all student clinical rotations with in-person patient care. This study is a quantitative analysis investigating the educational and psychological effects of the pandemic on US medical students and their reactions to the AAMC recommendation in order to inform medical education policy. Methods: The authors sent a cross-sectional survey via email to medical students in their clinical training years at six medical schools during the initial peak phase of the COVID-19 pandemic. Survey questions aimed to evaluate students’ perceptions of COVID-19’s impact on medical education; ethical obligations during a pandemic; infection risk; anxiety and burnout; willingness and needed preparations to return to clinical rotations. Results: Seven hundred forty-one (29.5%) students responded. Nearly all students (93.7%) were not involved in clinical rotations with in-person patient contact at the time the study was conducted. Reactions to being removed were mixed, with 75.8% feeling this was appropriate, 34.7% guilty, 33.5% disappointed, and 27.0% relieved. Most students (74.7%) agreed the pandemic had significantly disrupted their medical education, and believed they should continue with normal clinical rotations during this pandemic (61.3%). When asked if they would accept the risk of infection with COVID-19 if they returned to the clinical setting, 83.4% agreed. Students reported the pandemic had moderate effects on their stress and anxiety levels with 84.1% of respondents feeling at least somewhat anxious. Adequate personal protective equipment (PPE) (53.5%) was the most important factor to feel safe returning to clinical rotations, followed by adequate testing for infection (19.3%) and antibody testing (16.2%). Conclusions: The COVID-19 pandemic disrupted the education of US medical students in their clinical training years. The majority of students wanted to return to clinical rotations and were willing to accept the risk of COVID-19 infection. Students were most concerned with having enough PPE if allowed to return to clinical activities